Scientific offprints

Scientific offprints


A collection of approximately 125 offprints of historic experimental papers in 20th century biological sciences: biochemistry, cell biology, genetics, molecular biology. More than half of the items included are from winners of the Nobel Prize for Physiology or Medicine, or Chemistry and other prominent scientists are included. 

Highlights include: Seymour Benzer's revolutionary genetic mapping paper, “Fine Structure of a Genetic Region in Bacteriophage” (1955), Albert Claude,  “Fractionation of Mammalian Liver Cells by Differential Centrifugation,” (1949), Max Delbrück's seminal talk, “A Physicist Looks at Biology,” (1949); Alexander L. Dounce, “Duplicating Mechanism for Peptide Chain and Nucleic Acid Synthesis,” (1952), important early theoretical work on genetic coding and protein synthesis; H. Fraenkel-Conrat and Robley C. Williams, “Reconstitution of Active Tobacco Mosaic Virus from its Inactive Protein and Nucleic Acid Components,“ (1955) - the first reconstitution of a virus; J.C. Kendrew, G. Bodo, H.M. Dintzis, R.G. Parrish, H. Wyckoff, and D.C. Phillips, "A Three-dimensional Model of the Myoglobin Molecule Obtained by X-ray Analysis" (1958) - the first structural description of a protein.

 20 papers by H.G. Khorana, on nucleic acid synthesis and sequence analysis, establishing the basic techniques of nucleotide chemistry (1954-1962); Joshua Lederberg, “Gene Recombination and Linked Segregations in Escherichia Coli,” (1947) - the first genetic map of e. coli. E.L. Tatum and Joshua Lederberg, “Gene Recombination in the Bacterium Escherichia Coli,” (1947) is the  first complete paper on the subject of bacterial mating. André Lwoff, Louis Siminovitch and Niels Kjeldgaard, “Microbiologie – Induction de la production de bactériophages chez une bactérie lysogène,”(1950) - the discovery of induction, and another dozen important papers from Lwoff and his group; Jacques Monod, Germaine Cohen-Bazire and Melvin Cohn, “Sur la biosynthese de la β-galactosidase (lactase) chez Escherichia coli. La specificite de l’induction” (1951), - the discovery of galactosides, with other papers by Monod, Linus Pauling and Robert B. Corey, "A Proposed Structure for the Nucleic Acids” (1953) - Pauling's incorrect "triple helix" theory, and other Pauling papers.

 J.D. Watson, and F.H. Crick, “Molecular Study of Nucleic Acids: A Structure of Deoxyribose Nucleic Acid”.; M.F.H. Wilkins, A.R. Stokes, and H.R. Wilson. “Molecular Structure of Deoxypentose Nucleic Acids;”  Rosalind E. Franklin, and R.G. Gosling. “Molecular Configuration in Sodium Thymonucleate,” (1953). The rare three-paper offprint, printed in a single column format from, the single most important discovery in the biological sciences during the 20th century. 

M.H.F. Wilkins, W.E. Seeds, A.R. Stokes and H.R. Wilson, “Helical Structure of Crystalline Deoxypentose Nucleic Acid,” (1953), and Rosalind E. Franklin and R.G. Gosling, “Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate,” 1953) - the first experimental confirmation of the Watson-Crick double helix hypothesis, M. Meselson and F.W. Stahl.  "The Replication of DNA in Escherichia coli," (1958) - the first proof of semi-conservative replication of DNA, as predicted by Watson and Crick’s double helix model, termed "the most beautiful experiment in biology,"

Other authors represented include: Michael S. Brown and Joseph L. Goldstein (Nobel Prize 1985), S.S. Cohen, Arne Tiselius (Nobel Prize 1948), Robert W. Holley (Nobel Prize 1968), R. Dulbecco (Nobel Prize 1975), Ugo Fano, Leo Szilard.

Price for the collection: $150,000.00.   To view or download the inventory list: 


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