Inborn Errors of Metabolism. The Croonian Lectures. Archibald E. Garrod.

Inborn Errors of Metabolism. The Croonian Lectures

London: H. Frowde, 1909. First edition. Blue cloth, presumed first issue binding lettered in gilt on the spine, gilt and blind on the front cover. Withdrawn from the Royal Society of Medicine Library, to which it had been presented in 1916 by the opthamologist W.H.H. Jessop (gift bookplate); withdrawal stamps on title and contents pages, and rear pastedown; library markings on spine; a little wear to the cloth. The very scarce first edition. In 1908 Garrod "had shown that certain rare, inherited human disorders...were caused by the absence of specific enzymes....Garrod's inborn errors are often bracketed with Mendel's laws, and indeed with Avery's transforming principle, as cases of scientific prematurity" Judson, The Eighth Day of Creation, p. 214. "Since the inborn error was inherited and caused by a specific Mendelian factor, Garrod was introducing a link between a specific enzyme and a specific gene. He thus foreshadowed the one gene-one enzyme hypothesis that in the 1940's would be developed so effectively by George Wells Beadle and Edward L. Tatum and that has been central to the development of theories of gene action" D.S.B. "Garrod established chemical individuality as the paradigm of Mendelian variation" G-M 244.1 and 3921. Item #28838

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